Elucidating the chemical structure of native 1-deoxysphingosine[S]
The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the rare inherited neuropathy, HSAN1, and di...
Main Authors: | Regula Steiner, Essa M. Saied, Alaa Othman, Christoph Arenz, Alan T. Maccarone, Berwyck L.J. Poad, Stephen J. Blanksby, Arnold von Eckardstein, Thorsten Hornemann |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-07-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520351567 |
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