Cathepsin S and Protease-Activated Receptor-2 Drive Alloimmunity and Immune Regulation in Kidney Allograft Rejection

Cathepsin S and Protease-Activated Receptor-2 Drive Alloimmunity and Immune Regulation in Kidney Allograft Rejection

Alloantigen presentation is an essential process in acute allorejection. In this context, we speculated on a pathogenic role of cathepsin S (Cat-S), a cysteine protease known to promote antigenic peptide loading into MHC class II and to activate protease-activated receptor (PAR)-2 on intrarenal micr...

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Bibliographic Details
Main Authors: Yutian Lei, Benjamin Ehle, Santhosh V. Kumar, Susanne Müller, Solange Moll, Andrew F. Malone, Benjamin D. Humphreys, Joachim Andrassy, Hans-Joachim Anders
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
kidney transplantation
cathepsin S
allorejection
proteinase-activated receptor-2
animal model of transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00398/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00398/full

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