Simvastatin modulates mesenchymal stromal cell proliferation and gene expression.

Simvastatin modulates mesenchymal stromal cell proliferation and gene expression.

Statins are widely used hypocholesterolemic drugs that block the mevalonate pathway, responsible for the biosysnthesis of cholesterol. However, statins also have pleiotropic effects that interfere with several signaling pathways. Mesenchymal stromal cells (MSC) are a heterogeneous mixture of cells t...

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Bibliographic Details
Main Authors: Dalila Lucíola Zanette, Julio Cesar Cetrulo Lorenzi, Rodrigo Alexandre Panepucci, Patricia Vianna Bonini Palma, Daiane Fernanda Dos Santos, Karen Lima Prata, Wilson Araújo Silva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4395223?pdf=render

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http://europepmc.org/articles/PMC4395223?pdf=render

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