Calcium sensing by the STIM1 ER-luminal domain
Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological activation of STIM1 in cells.
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-06816-8 |