Calcium sensing by the STIM1 ER-luminal domain

Calcium sensing by the STIM1 ER-luminal domain

Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological activation of STIM1 in cells.

Bibliographic Details
Main Authors: Aparna Gudlur, Ana Eliza Zeraik, Nupura Hirve, V. Rajanikanth, Andrey A. Bobkov, Guolin Ma, Sisi Zheng, Youjun Wang, Yubin Zhou, Elizabeth A. Komives, Patrick G. Hogan
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06816-8

Internet

https://doi.org/10.1038/s41467-018-06816-8

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