HIV LTR-Driven Antisense RNA by Itself Has Regulatory Function and May Curtail Virus Reactivation From Latency

HIV LTR-Driven Antisense RNA by Itself Has Regulatory Function and May Curtail Virus Reactivation From Latency

Latently infected T lymphocytes are an important barrier toward eliminating a persistent HIV infection. Here we describe an HIV-based recombinant fluorescent-lentivirus referred to as “rfl-HIV” that enables to analyze sense and antisense transcription by means of fluorescence reporter genes. This mo...

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Bibliographic Details
Main Authors: Mie Kobayashi-Ishihara, Kazutaka Terahara, Javier P. Martinez, Makoto Yamagishi, Ryutaro Iwabuchi, Christian Brander, Manabu Ato, Toshiki Watanabe, Andreas Meyerhans, Yasuko Tsunetsugu-Yokota
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
HIV
viral antisense RNA
latency
reactivation
latency reversing agents
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01066/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01066/full

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