The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis

High levels of collagen deposition in human and mouse breast tumors are associated with poor outcome due to increased local invasion and distant metastases. Using a genetic approach, we show that, in mice, the action of the fibrillar collagen receptor discoidin domain receptor 2 (DDR2) in both tumor...

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Bibliographic Details
Main Authors: Callie A.S. Corsa, Audrey Brenot, Whitney R. Grither, Samantha Van Hove, Andrew J. Loza, Kun Zhang, Suzanne M. Ponik, Yuming Liu, David G. DeNardo, Kevin W. Eliceiri, Patricia J. Keely, Gregory D. Longmore
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306167

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http://www.sciencedirect.com/science/article/pii/S2211124716306167

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