Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease

Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease

Progression of chronic kidney disease remains a principal problem in clinical nephrology and there is a pressing need for novel therapeutics and biomarkers. Aberrant promoter CpG island methylation and subsequent transcriptional silencing of specific genes have emerged as contributors to progression...

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Bibliographic Details
Main Authors: Björn Tampe, Desiree Tampe, Elisabeth M. Zeisberg, Gerhard A. Müller, Wibke Bechtel-Walz, Michael Koziolek, Raghu Kalluri, Michael Zeisberg
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:EBioMedicine
Subjects:
Epigenetics
DNA methylation
Fibrosis
Ten-Eleven Translocation (TET)
De-methylation
RASAL1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396414000292

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http://www.sciencedirect.com/science/article/pii/S2352396414000292

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