Hyperglycemia Potentiates Prothrombotic Effect of Aldosterone in a Rat Arterial Thrombosis Model

Hyperglycemia Potentiates Prothrombotic Effect of Aldosterone in a Rat Arterial Thrombosis Model

We investigated the role of aldosterone (ALDO) in the development of arterial thrombosis in streptozotocin-induced diabetic rats. To evaluate the effect of endogenous ALDO, the rats underwent adrenalectomy (ADX). ADX reduced the development of arterial thrombosis. A 1 h infusion of ALDO (30 μg/kg/h)...

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Bibliographic Details
Main Authors: Anna Gromotowicz-Poplawska, Piotr Szoka, Agnieszka Zakrzeska, Patrycjusz Kolodziejczyk, Natalia Marcinczyk, Janusz Szemraj, Piotr Tutka, Ewa Chabielska
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
aldosterone
adrenalectomy
diabetes
thrombosis
mineralocorticoid receptor
glucocorticoid receptor
Online Access:https://www.mdpi.com/2073-4409/10/2/471

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https://www.mdpi.com/2073-4409/10/2/471

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