Alu insertion/deletion of ACE gene polymorphism might not affect significantly the serum bradykinin level in hypertensive patients taking ACE inhibitors

Alu insertion/deletion of ACE gene polymorphism might not affect significantly the serum bradykinin level in hypertensive patients taking ACE inhibitors

Background: Angiotensin I-converting enzyme (ACE) has two homologous catalytic domains, the N- and C-domains. Our previous study suggested that Alu insertion (I allele) in the intron 16 of ACE resulted in premature codon termination. The I allele has only one active site in the N-domain while the Al...

Full description

Bibliographic Details
Main Authors: Widodo, Shila Wisnasari, Mohammad Saifur Rohman, Lowry Yunita, Mifetika Lukitasari, Maulidiyatun Nuril, Kholifah Holil, Dian Laila Purwaningroom
Format: Article
Language:English
Published: SpringerOpen 2017-04-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Binding affinity
Angiotensin
Bradykinin
I/D variant ACE
ACE inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S1110863016300519

Internet

http://www.sciencedirect.com/science/article/pii/S1110863016300519

Similar Items