Deletion of Btg1 Induces Prmt1-Dependent Apoptosis and Increased Stemness in Shh-Type Medulloblastoma Cells Without Affecting Tumor Frequency

Deletion of Btg1 Induces Prmt1-Dependent Apoptosis and Increased Stemness in Shh-Type Medulloblastoma Cells Without Affecting Tumor Frequency

About 30% of medulloblastomas (MBs), a tumor of the cerebellum, arise from cerebellar granule cell precursors (GCPs) undergoing transformation following activation of the Sonic hedgehog (Shh) pathway. To study this process, we generated a new MB model by crossing Patched1 heterozygous (Ptch1+/−) mic...

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Bibliographic Details
Main Authors: Manuela Ceccarelli, Giorgio D'Andrea, Laura Micheli, Felice Tirone
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
cerebellum neurogenesis
medulloblastoma
neoplastic granule cell precursors
apoptosis
proliferation
protein arginine methyltransferase 1 (Prmt1)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00226/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00226/full

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