Lupin protein exerts cholesterol-lowering effects targeting PCSK9: From clinical evidences to elucidation of the in vitro molecular mechanism using HepG2 cells

Lupin protein exerts cholesterol-lowering effects targeting PCSK9: From clinical evidences to elucidation of the in vitro molecular mechanism using HepG2 cells

PCSK9 inhibition is a novel approach for cholesterol reduction because of its crucial pathophysiological role in cholesterol metabolism. This work aimed at evaluating whether lupin protein/peptides may modulate PCSK9 production. Mild hypercholesterolaemic subjects consumed lupin protein or casein (3...

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Bibliographic Details
Main Authors: Carmen Lammi, Chiara Zanoni, Laura Calabresi, Anna Arnoldi
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Journal of Functional Foods
Subjects:
Bioactive peptides
HepG2 cells
HNF1-alpha
Lupinus
PCSK9
Plant proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616000980

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http://www.sciencedirect.com/science/article/pii/S1756464616000980

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