Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice

Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice

Background: Myocardial infarction (MI) is caused by occlusion of the coronary artery and induces ischemia in the myocardium and eventually a massive loss in cardiomyocytes. Studies have shown many factors or treatments that can affect the healing and remodeling of the heart upon infarction, leading...

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Bibliographic Details
Main Authors: Zhiyong Lei, Juntao Fang, Janine C. Deddens, Corina H. G. Metz, Esther C. M. van Eeuwijk, Hamid el Azzouzi, Pieter A. Doevendans, Joost P. G. Sluijter
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
miR-132/212
myocardial infarction
cardiac function
adverse cardiac remodeling
permanent coronary occlusion
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00590/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.00590/full

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