Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade

Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade

Background: Several efforts have been made to develop effective antipsychotic drugs. Currently, available antipsychotics are effective on positive symptoms, less on negative symptoms, but not on cognitive impairment, a clinically relevant dimension of schizophrenia. Drug repurposing offers great adv...

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Bibliographic Details
Main Authors: Sebastiano Alfio Torrisi, Salvatore Salomone, Federica Geraci, Filippo Caraci, Claudio Bucolo, Filippo Drago, Gian Marco Leggio
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
buspirone
dopamine D3 receptor
MK-801
schizophrenia
antipsychotics
prepulse inhibition
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00710/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00710/full

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