Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer

Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer

Abstract Background The TG-interacting factor 1 (TGIF1) gene, which encodes a nuclear transcriptional corepressor of the TGFβ1/Smad signaling pathway, has been implicated in the pathogenesis of various types of human cancer; however, its role in pancreatic ductal adenocarcinoma (PDAC) has yet to be...

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Bibliographic Details
Main Authors: Ching-Chieh Weng, Mei-Jen Hsieh, Chia-Chen Wu, Yu-Chun Lin, Yan-Shen Shan, Wen-Chun Hung, Li-Tzong Chen, Kuang-Hung Cheng
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Molecular Cancer
Subjects:
Pancreatic cancer
TGIF1
Has2
PD-L1
M2 macrophage
Metastatic PDAC model
Online Access:http://link.springer.com/article/10.1186/s12943-019-1023-1

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http://link.springer.com/article/10.1186/s12943-019-1023-1

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