Sequestration of Late Antigens Within Viral Factories Impairs MVA Vector-Induced Protective Memory CTL Responses

Sequestration of Late Antigens Within Viral Factories Impairs MVA Vector-Induced Protective Memory CTL Responses

Cytotoxic CD8+ T cell (CTL) responses play an essential role in antiviral immunity. Here, we focused on the activation of CTL which recognize epitopes derived from viral or recombinant antigens with either early or late expression kinetics after infection with Modified Vaccinia Virus Ankara (MVA). L...

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Bibliographic Details
Main Authors: Sha Tao, Ronny Tao, Dirk H. Busch, Marek Widera, Heiner Schaal, Ingo Drexler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
CTL
antigen presentation
Modified Vaccinia Virus Ankara (MVA)
memory T cell activation
viral vector vaccine
viral immunology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02850/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02850/full

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