Identification of a Gene Signature Closely Related to Immunosuppressive Tumour Microenvironment Predicting Prognosis of Patients in EGFR Mutant Lung Adenocarcinoma

Identification of a Gene Signature Closely Related to Immunosuppressive Tumour Microenvironment Predicting Prognosis of Patients in EGFR Mutant Lung Adenocarcinoma

Lung adenocarcinomas (LUADs) harbouring epidermal growth factor receptor (EGFR) mutations are generally unable to benefit from immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumour microenvironment (TME) and a lower tumour mutation burden. Currently, no gene signature can comprehens...

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Bibliographic Details
Main Authors: Jia Li, Huahua Li, Chenyue Zhang, Chenxing Zhang, Lifeng Jiang, Haiyong Wang, Huaimin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
lung adenocarcinoma
mutation
gene signature
tumour microenvironment
tumour mutation burden
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.732841/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.732841/full

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