Fine-Tuning of Alkaline Residues on the Hydrophilic Face Provides a Non-toxic Cationic α-Helical Antimicrobial Peptide Against Antibiotic-Resistant ESKAPE Pathogens

Fine-Tuning of Alkaline Residues on the Hydrophilic Face Provides a Non-toxic Cationic α-Helical Antimicrobial Peptide Against Antibiotic-Resistant ESKAPE Pathogens

Antibiotic-resistant ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) has become a serious threat to public health worldwide. Cationic α-helical antimicrobial peptides (CαAMPs) have attrac...

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Bibliographic Details
Main Authors: Xudong Luo, Xiangdong Ye, Li Ding, Wen Zhu, Pengcheng Yi, Zhiwen Zhao, Huanhuan Gao, Zhan Shu, Shan Li, Ming Sang, Jue Wang, Weihua Zhong, Zongyun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Microbiology
Subjects:
ESKAPE pathogens
antibiotic resistance
cationic α-helical antimicrobial peptide
hydrophilic face
lysine vs arginine
hemolytic activity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.684591/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.684591/full

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