Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation

Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation

Abstract We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationships with sodium butyrate, a histone deacetylase inhibitor, on the hippocampal func...

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Bibliographic Details
Main Authors: Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Dae Won Kim, Jung Hoon Choi, Jin Young Chung, Moo-Ho Won, Yeo Sung Yoon, In Koo Hwang
Format: Article
Language:English
Published: BMC 2016-12-01
Series:Laboratory Animal Research
Subjects:
AK-7
neurogenesis
novel object recognition test
sirtuin 2
sodium butyrate
Online Access:http://link.springer.com/article/10.5625/lar.2016.32.4.224

Internet

http://link.springer.com/article/10.5625/lar.2016.32.4.224

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