Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-κB activation.

Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-κB activation.

OBJECTIVE: SIRT1 modulates the acetylation of the p65 subunit of nuclear factor-κB (NF-κB) and plays a pivotal role in the inflammatory response. This study sought to assess the role of SIRT1 in rheumatoid arthritis (RA) using a myeloid cell-specific SIRT1 knockout (mSIRT1 KO) mouse. METHODS: mSIRT1...

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Main Authors: Young-Sool Hah, Yun-Hong Cheon, Hye Song Lim, Hee Young Cho, Byung-Hyun Park, Sun-O Ka, Young-Rae Lee, Dong-Won Jeong, Hyun-Ok Kim, Myung-Kwan Han, Sang-Il Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3912001?pdf=render

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http://europepmc.org/articles/PMC3912001?pdf=render

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