Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells

Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells

Acute myeloid leukemia (AML) is the most lethal form of leukemia. Standard anti-AML treatment remains almost unchanged for decades. Tingenone (TG) and 22-hydroxytingenone (22-HTG) are quinonemethide triterpenes found in the Amazonian plant Salacia impressifolia (Celastraceae), with cytotoxic propert...

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Bibliographic Details
Main Authors: Ana Carolina B. da C. Rodrigues, Larissa M. Bomfim, Sara P. Neves, Milena B.P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Emmanoel V. Costa, Felipe M.A. da Silva, Waldireny C. Rocha, Hector H.F. Koolen, Daniel P. Bezerra
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tingenone
22-hydroxytingenone
Thioredoxin
Oxidative stress
Apoptosis
AML
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221008179

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http://www.sciencedirect.com/science/article/pii/S0753332221008179

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