Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer

Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer

Abstract Background Breast cancer is the most prevalent cancer among women worldwide. WZ35, an analog of curcumin, has been demonstrated to remarkably improve the pharmacokinetic profiles in vivo compared with curcumin. WZ35 exhibits promising antitumor activity in gastric cancer, HCC, colon cancer....

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Bibliographic Details
Main Authors: Lihua Wang, Canwei Wang, Zheying Tao, Liqian Zhao, Zheng Zhu, Wencan Wu, Ye He, Hong Chen, Bin Zheng, Xiangjie Huang, Yun Yu, Linjun Yang, Guang Liang, Ri Cui, Tongke Chen
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast Cancer
WZ35
YAP
ROS
JNK
Mitochondrial dysfunction
Online Access:http://link.springer.com/article/10.1186/s13046-019-1424-4

Internet

http://link.springer.com/article/10.1186/s13046-019-1424-4

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