Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.

Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.

OBJECTIVE:Diabetes and low back pain are debilitating diseases and modern epidemics. Diabetes and obesity are also highly correlated with intervertebral disc (IVD) degeneration and back pain. Advanced-glycation-end-products (AGEs) increase reactive-oxygen-species (ROS) and inflammation, and are one...

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Bibliographic Details
Main Authors: Svenja Illien-Junger, Fabrizio Grosjean, Damien M Laudier, Helen Vlassara, Gary E Striker, James C Iatridis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3656842?pdf=render

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http://europepmc.org/articles/PMC3656842?pdf=render

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