Cracking the Breast Cancer Glyco-Code through Glycan-Lectin Interactions: Targeting Immunosuppressive Macrophages

Cracking the Breast Cancer Glyco-Code through Glycan-Lectin Interactions: Targeting Immunosuppressive Macrophages

The immune microenvironment of breast cancer (BC) is composed by high macrophage infiltrates, correlated with the most aggressive subtypes. Tumour-associated macrophages (TAM) within the BC microenvironment are key regulators of immune suppression and BC progression. Nevertheless, several key questi...

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Bibliographic Details
Main Authors: Nuno Lopes, Viviana G. Correia, Angelina S. Palma, Catarina Brito
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
tumour microenvironment
tumour-associated macrophages
aberrant glycosylation
glycan-lectin interactions
immunotherapy
Online Access:https://www.mdpi.com/1422-0067/22/4/1972

Internet

https://www.mdpi.com/1422-0067/22/4/1972

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