Chemoradiotherapy Increases Intratumor Heterogeneity of HPSE Expression in the Relapsed Glioblastoma Tumors

Chemoradiotherapy Increases Intratumor Heterogeneity of HPSE Expression in the Relapsed Glioblastoma Tumors

Adjuvant chemoradiotherapy is a standard treatment option for glioblastoma multiforme (GBM). Despite intensive care, recurrent tumors developed during the first year are fatal for the patients. Possibly contributing to this effect, among other causes, is that therapy induces changes of polysaccharid...

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Bibliographic Details
Main Authors: Anastasia V. Suhovskih, Galina M. Kazanskaya, Alexander M. Volkov, Alexandra Y. Tsidulko, Svetlana V. Aidagulova, Elvira V. Grigorieva
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma multiforme
adjuvant chemoradiotherapy
disease relapse
heparan sulfate
heparanase expression
intratumor heterogeneity
Online Access:https://www.mdpi.com/1422-0067/21/4/1301

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https://www.mdpi.com/1422-0067/21/4/1301

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