Inhibition of CPT1a as a prognostic marker can synergistically enhance the antileukemic activity of ABT199

Inhibition of CPT1a as a prognostic marker can synergistically enhance the antileukemic activity of ABT199

Abstract Background Fatty acid oxidation (FAO) provides an important source of energy to promote the growth of leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme of the essential step of FAO, can facilitate cancer metabolic adaptation. Previous reports demonstrated that...

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Bibliographic Details
Main Authors: Shihui Mao, Qing Ling, Jiajia Pan, Fenglin Li, Shujuan Huang, Wenle Ye, Wenwen Wei, Xiangjie Lin, Yu Qian, Yungui Wang, Xin Huang, Jiansong Huang, Jinghan Wang, Jie Jin
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Translational Medicine
Subjects:
ABT199
Carnitine palmitoyltransferase 1
Fatty acid oxidation
Oncogene
Acute myeloid leukemia
Online Access:https://doi.org/10.1186/s12967-021-02848-9

Internet

https://doi.org/10.1186/s12967-021-02848-9

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