Intrathecal pemetrexed combined with involved-field radiotherapy as a first-line intra-CSF therapy for leptomeningeal metastases from solid tumors: a phase I/II study

Intrathecal pemetrexed combined with involved-field radiotherapy as a first-line intra-CSF therapy for leptomeningeal metastases from solid tumors: a phase I/II study

Purpose: A phase I/II study of intrathecal pemetrexed (IP) combined with involved-field radiotherapy (IFRT) was performed to determine feasibility, safety, and antitumor activity for leptomeningeal metastases (LM) from solid tumors. Methods: Participants first received induction IP administration, f...

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Main Authors: Zhenyu Pan, Guozi Yang, Hua He, Jiuwei Cui, Wei Li, Tingting Yuan, Kunzhi Chen, Tongchao Jiang, Pengxiang Gao, Yanan Sun, Xiaofeng Cong, Zhi Li, Yongxiang Wang, Xiaochuan Pang, Yuanyuan Song, Gang Zhao
Format: Article
Language:English
Published: SAGE Publishing 2020-07-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758835920937953

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https://doi.org/10.1177/1758835920937953

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