Targeting Tumor Vascular CD99 Inhibits Tumor Growth

Targeting Tumor Vascular CD99 Inhibits Tumor Growth

CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker for Ewing's Sarcoma (EWS), as it is high...

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Bibliographic Details
Main Authors: Elisabeth J. M. Huijbers, Inge M. van der Werf, Lisette D. Faber, Lena D. Sialino, Pia van der Laan, Hanna A. Holland, Anca M. Cimpean, Victor L. J. L. Thijssen, Judy R. van Beijnum, Arjan W. Griffioen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
CD99
MIC2
angiogenesis
tumor vasculature
vaccination
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00651/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00651/full

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