Metabolism of Gluconeogenic Substrates by an Intracellular Fungal Pathogen Circumvents Nutritional Limitations within Macrophages

Metabolism of Gluconeogenic Substrates by an Intracellular Fungal Pathogen Circumvents Nutritional Limitations within Macrophages

Histoplasma is a primary human fungal pathogen that survives and proliferates within host immune cells, particularly within the macrophage phagosome compartment. The phagosome compartment is a nutrient-limited environment, requiring Histoplasma yeasts to be able to assimilate available carbon source...

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Bibliographic Details
Main Authors: Qian Shen, Stephanie C. Ray, Heather M. Evans, George S. Deepe, Chad A. Rappleye
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
histoplasma
carbon metabolism
intracellular pathogens
macrophages
pathogenesis
phagosomes
virulence
Online Access:https://doi.org/10.1128/mBio.02712-19

Internet

https://doi.org/10.1128/mBio.02712-19

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