Down-regulation of NDRG1 promotes migration of cancer cells during reoxygenation.

One characteristic of tumor microenvironment is oxygen fluctuation, which results from hyper-proliferation and abnormal metabolism of tumor cells as well as disorganized neo-vasculature. Reoxygenation of tumors can induce oxidative stress, which leads to DNA damage and genomic instability. Although...

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Bibliographic Details
Main Authors: Liang-Chuan Lai, Yi-Yu Su, Kuo-Chih Chen, Mong-Hsun Tsai, Yuh-Pyng Sher, Tzu-Pin Lu, Chien-Yueh Lee, Eric Y Chuang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21912630/pdf/?tool=EBI