The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT

The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT

The <i>RORC</i> (RAR related orphan receptor C) gene produces two isoforms by alternative promoter usage: ROR&#947; (nuclear receptor ROR-gamma isoform 1) and ROR&#947;T (nuclear receptor ROR-gamma isoform 1). Both proteins have distinct tissue distributions and are involved in s...

Full description

Bibliographic Details
Main Authors: Kaja Karaś, Anna Sałkowska, Iwona Karwaciak, Aurelia Walczak-Drzewiecka, Jarosław Dastych, Rafał A. Bachorz, Marcin Ratajewski
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
rorgamma (nuclear receptor ror-gamma isoform 1)
rorgammat (nuclear receptor ror-gamma isoform 1)
rorc (rar related orphan receptor c)
th17 (t helper 17 cell)
az5104
egfr (epidermal growth factor receptor)
Online Access:https://www.mdpi.com/1422-0067/20/22/5780

Internet

https://www.mdpi.com/1422-0067/20/22/5780

Similar Items