Interleukin-6 Knockout Inhibits Senescence of Bone Mesenchymal Stem Cells in High-Fat Diet-Induced Bone Loss

Interleukin-6 Knockout Inhibits Senescence of Bone Mesenchymal Stem Cells in High-Fat Diet-Induced Bone Loss

Obesity, a chronic low-grade inflammatory state, not only promotes bone loss, but also accelerates cell senescence. However, little is known about the mechanisms that link obesity, bone loss, and cell senescence. Interleukin-6 (IL-6), a pivotal inflammatory mediator increased during obesity, is a ca...

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Bibliographic Details
Main Authors: Yujue Li, Lingyun Lu, Ying Xie, Xiang Chen, Li Tian, Yan Liang, Huifang Li, Jie Zhang, Yi Liu, Xijie Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
IL-6
obesity
osteoporosis
senecence
bone mesenchymal stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.622950/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.622950/full

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