JAK3/STAT5/6 Pathway Alterations Are Associated with Immune Deviation in CD8+ T Cells in Renal Cell Carcinoma Patients

JAK3/STAT5/6 Pathway Alterations Are Associated with Immune Deviation in CD8+ T Cells in Renal Cell Carcinoma Patients

To investigate the molecular mechanisms underlying altered T cell response in renal cell carcinoma (RCC) patients, we compared autologous and allogeneic CD8+ T cell responses against RCC line from RCC patients and their HLA-matched donors, using mixed lymphocyte/tumor cell cultures (MLTCs). In addit...

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Bibliographic Details
Main Authors: Elisabetta Cavalcanti, Margherita Gigante, Vito Mancini, Michele Battaglia, Pasquale Ditonno, Carmela Capobianco, Raffaele I. Cincione, Francesco P. Selvaggi, Wolfgang Herr, Walter J. Storkus, Loreto Gesualdo, Elena Ranieri
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2010/935764

Internet

http://dx.doi.org/10.1155/2010/935764

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