Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

Abstract Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). All diseases are determined by αS aggregate deposition but can be separ...

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Bibliographic Details
Main Authors: Richard M. Meade, David P. Fairlie, Jody M. Mason
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Molecular Neurodegeneration
Subjects:
Alpha-synuclein
Amyloid
Oligomers
Parkinson’s disease
Protein-protein interactions
CryoEM
Online Access:http://link.springer.com/article/10.1186/s13024-019-0329-1

Internet

http://link.springer.com/article/10.1186/s13024-019-0329-1

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