Reciprocal Regulation Between Smad7 and Sirt1 in the Gut

Reciprocal Regulation Between Smad7 and Sirt1 in the Gut

In inflammatory bowel disease (IBD) mucosa, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine transforming growth factor-β1, due to post-transcriptional mechanisms that enhance Smad7 acetylation status thus preventing ubiquitination-mediated proteosomal degrad...

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Bibliographic Details
Main Authors: Silvia Sedda, Eleonora Franzè, Gerolamo Bevivino, Martina Di Giovangiulio, Angelamaria Rizzo, Alfredo Colantoni, Angela Ortenzi, Enrico Grasso, Mario Giannelli, Giuseppe S. Sica, Massimo Claudio Fantini, Giovanni Monteleone
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
mucosal inflammation
colitis
transforming growth factor-β
Sirt1
inflammatory bowel diseases
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01854/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01854/full

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