Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant join...

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Bibliographic Details
Main Authors: Chloé Lescale, Hélène Lenden Hasse, Andrew N. Blackford, Gabriel Balmus, Joy J. Bianchi, Wei Yu, Léa Bacoccina, Angélique Jarade, Christophe Clouin, Rohan Sivapalan, Bernardo Reina-San-Martin, Stephen P. Jackson, Ludovic Deriano
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
V(D)J recombination
DNA repair
NHEJ
PAXX
XLF
XRCC4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311652

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http://www.sciencedirect.com/science/article/pii/S2211124716311652

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