Effects of intraventricular methotrexate administration on Cuprizone-induced demyelination in mice

Effects of intraventricular methotrexate administration on Cuprizone-induced demyelination in mice

We previously showed that intrathecal administration of methotrexate slowed disability progression in multiple sclerosis patients with progressive disease. In general MS patients with progressive disease respond poorly to anti-inflammatory therapies. In order to better understand the mechanism by wh...

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Bibliographic Details
Main Authors: Andre Michael Mueller, Adam eNassery, Hana eConlon, Xinhe eLiu, Massimiliano eCristofanilli, Esther eJun, Bo Hyung eYoon, Saud Ahmed Sadiq
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Astrocytes
Methotrexate
Multiple Sclerosis
EAE
IGF1
demyelination
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00034/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00034/full

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