Effects of intraventricular methotrexate administration on Cuprizone-induced demyelination in mice
We previously showed that intrathecal administration of methotrexate slowed disability progression in multiple sclerosis patients with progressive disease. In general MS patients with progressive disease respond poorly to anti-inflammatory therapies. In order to better understand the mechanism by wh...
Main Authors: | Andre Michael Mueller, Adam eNassery, Hana eConlon, Xinhe eLiu, Massimiliano eCristofanilli, Esther eJun, Bo Hyung eYoon, Saud Ahmed Sadiq |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2013-10-01
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Series: | Frontiers in Molecular Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00034/full |
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