Mutation of the conserved GRG motif and decreasing activity of human RNase H2

Mutation of the conserved GRG motif and decreasing activity of human RNase H2

RNase H2 consists of three subunits (H2A, H2B and H2C) and is involved in the hydrolysis of RNA/DNA hybrids. The GRG motif in RNase H2 is highly conserved and recognizes the ribonucleotides misincorporated into dsDNA. The mutant G37S in the GRG motif of human RNase H2A was found to be correlated wit...

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Bibliographic Details
Main Authors: Li Lin, Shen Wanxiang, Zheng Jing, Lai Raofang, Tan Chunyan, Tan Ying, Jiang Yuyang
Format: Article
Language:English
Published: De Gruyter 2015-06-01
Series:Open Life Sciences
Subjects:
RNase H2
GRG motif
RNA/DNA hybrids
sitedirected mutation
cleavage activity
binding activity
Online Access:http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0033/biol-2015-0033.xml?format=INT

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http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0033/biol-2015-0033.xml?format=INT

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