Supersaturation induced by Itraconazole/Soluplus® micelles provided high GI absorption in vivo

Supersaturation induced by Itraconazole/Soluplus® micelles provided high GI absorption in vivo

To investigate the effect of supersaturation induced by micelle formation during dissolution on the bioavailability of itraconazole (ITZ)/Soluplus® solid dispersion. Solid dispersions prepared by hot melt extrusion (HME) were compressed into tablets directly with other excipients. Dissolution behavi...

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Bibliographic Details
Main Authors: Yue Zhong, Guanghui Jing, Bin Tian, Hao Huang, Yuanyuan Zhang, Jingxin Gou, Xing Tang, Haibing He, Yanjiao Wang
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Solid dispersion
Itraconazole tablets
Hot melt extrusion
Supersaturation
Micelles
Bioavailability
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087615000586

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http://www.sciencedirect.com/science/article/pii/S1818087615000586

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