Effects of Cyclic Mechanical Stretch on the Proliferation of L6 Myoblasts and Its Mechanisms: PI3K/Akt and MAPK Signal Pathways Regulated by IGF-1 Receptor

Effects of Cyclic Mechanical Stretch on the Proliferation of L6 Myoblasts and Its Mechanisms: PI3K/Akt and MAPK Signal Pathways Regulated by IGF-1 Receptor

Myoblast proliferation is crucial to skeletal muscle hypertrophy and regeneration. Our previous study indicated that mechanical stretch altered the proliferation of C2C12 myoblasts, associated with insulin growth factor 1 (IGF-1)-mediated phosphoinositide 3-kinase (PI3K)/Akt (also known as protein k...

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Bibliographic Details
Main Authors: Shaoting Fu, Lijun Yin, Xiaojing Lin, Jianqiang Lu, Xiaohui Wang
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
cyclic mechanic stretch
L6 myoblasts
proliferation
IGF-1
PI3K/Akt
MAPKs
Online Access:http://www.mdpi.com/1422-0067/19/6/1649

Internet

http://www.mdpi.com/1422-0067/19/6/1649

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