KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.

KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.

Obesity places major demands on the protein folding capacity of the endoplasmic reticulum (ER), resulting in ER stress, a condition that promotes hepatic insulin resistance and steatosis. Here we identify the transcription factor, Kruppel-like factor 15 (KLF15), as an essential mediator of ER stress...

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Bibliographic Details
Main Authors: Dae Young Jung, Umadevi Chalasani, Ning Pan, Randall H Friedline, Domenick A Prosdocimo, Minwoo Nam, Yoshihiro Azuma, Rajanikanth Maganti, Kristine Yu, Ashish Velagapudi, Bryan O'Sullivan-Murphy, Juliano L Sartoretto, Mukesh K Jain, Marcus P Cooper, Fumihiko Urano, Jason K Kim, Susan Gray
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805598?pdf=render

Internet

http://europepmc.org/articles/PMC3805598?pdf=render

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