STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3

Mountainous evidence suggests that inflammation, cardiomyocyte apoptosis and pyroptosis are involved in the development of sepsis and sepsis-induced cardiomyopathy (SIC). Stimulator of interferon genes (STING) is an indispensable molecule that could regulate inflammation and immune response in multi...

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Bibliographic Details
Main Authors: Ning Li, Heng Zhou, Haiming Wu, Qingqing Wu, Mingxia Duan, Wei Deng, Qizhu Tang
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719303611