Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients.

Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients.

Acute pyelonephritis (APN), which is mainly caused by uropathogenic Escherichia coli (UPEC), is the most common bacterial complication in renal transplant recipients receiving immunosuppressive treatment. However, it remains unclear how immunosuppressive drugs, such as the calcineurin inhibitor cycl...

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Bibliographic Details
Main Authors: Emilie Tourneur, Sanae Ben Mkaddem, Cécilia Chassin, Marcelle Bens, Jean-Michel Goujon, Nicolas Charles, Christophe Pellefigues, Meryem Aloulou, Alexandre Hertig, Renato C Monteiro, Stephen E Girardin, Dana J Philpott, Eric Rondeau, Carole Elbim, Catherine Werts, Alain Vandewalle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3561241?pdf=render

Internet

http://europepmc.org/articles/PMC3561241?pdf=render

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