A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice

Alzheimer’s disease (AD) is the leading cause of dementia. Non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist memantine improved cognition and molecular alterations after preclinical treatment. Nevertheless, clinical results are discouraging. In vivo efficacy of the RL-208, a...

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Bibliographic Details
Main Authors: Júlia Companys-Alemany, Andreea L. Turcu, Aina Bellver-Sanchis, Maria I Loza, José M. Brea, Anna M Canudas, Rosana Leiva, Santiago Vázquez, Mercè Pallàs, Christian Griñán-Ferré
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/12/3/284