Saccharomyces cerevisiae: First Steps to a Suitable Model System To Study the Function and Intracellular Transport of Human Kidney Anion Exchanger 1

Saccharomyces cerevisiae: First Steps to a Suitable Model System To Study the Function and Intracellular Transport of Human Kidney Anion Exchanger 1

Distal renal tubular acidosis (dRTA) is a common kidney dysfunction characterized by impaired acid secretion via urine. Previous studies revealed that α-intercalated cells of dRTA patients express mutated forms of human kidney anion exchanger 1 (kAE1) which result in inefficient plasma membrane targ...

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Bibliographic Details
Main Authors: Hasib A. M. Sarder, Xiaobing Li, Charlotta Funaya, Emmanuelle Cordat, Manfred J. Schmitt, Björn Becker
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mSphere
Subjects:
s. cerevisiae
model organism
kidney anion exchanger 1 (kae1)
heterologous expression
electron microscopy
ph
anion exchange
plasma membrane transport
Online Access:https://doi.org/10.1128/mSphere.00802-19

Internet

https://doi.org/10.1128/mSphere.00802-19

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