Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca2+-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels

Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca2+-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels

Fracture healing and bone regeneration, particularly in the elderly, remains a challenge. There is an ongoing search for methods to activate osteoblasts, and the application of electrical fields is an attractive approach in this context. Although it is known that such electromagnetic fields lead to...

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Bibliographic Details
Main Authors: Marco Rohde, Josefin Ziebart, Timo Kirschstein, Tina Sellmann, Katrin Porath, Friederike Kühl, Bachir Delenda, Christian Bahls, Ursula van Rienen, Rainer Bader, Rüdiger Köhling
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
galvanotaxis
osteoblasts
cell migration
TRP channels
bone regeneration
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00422/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2019.00422/full

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