Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy

Tauopathy is a type of dementia defined by the accumulation of filamentous tau inclusions in neural cells. Most types of dementia in the elderly, including Alzheimer’s disease, are tauopathies. Although it is believed that tau protein abnormalities and/or the loss of its functions results in neurode...

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Bibliographic Details
Main Authors: Tomohiro Miyasaka, Yuki Shinzaki, Satomi Yoshimura, Sawako Yoshina, Eriko Kage-Nakadai, Shohei Mitani, Yasuo Ihara
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neuroscience
Subjects:
tau
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00415/full