Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice

Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice

Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell de...

Full description

Bibliographic Details
Main Authors: Yuki Ishimaru, Akihide Sumino, Daiki Kajioka, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Apelin
APJ
Knockout mouse
Neuroprotection
Retina
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316301700

Internet

http://www.sciencedirect.com/science/article/pii/S1347861316301700

Similar Items