Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

Abstract Background While regulated WNT activity is required for normal development and stem cell maintenance, mutations that lead to constitutive activation of the WNT pathway cause cellular transformation and drive colorectal cancer. Activation of the WNT pathway ultimately leads to the nuclear tr...

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Bibliographic Details
Main Authors: Yi-Heng Hao, M. Carmen Lafita-Navarro, Lauren Zacharias, Nofit Borenstein-Auerbach, Min Kim, Spencer Barnes, Jiwoong Kim, Jerry Shay, Ralph J. DeBerardinis, Maralice Conacci-Sorrell
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cell Communication and Signaling
Subjects:
MYC
WNT/β-catenin pathway
LEF1
Colon cancer
Tumorigenesis
Metabolism
Online Access:http://link.springer.com/article/10.1186/s12964-019-0444-1

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http://link.springer.com/article/10.1186/s12964-019-0444-1

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