TROAP switches DYRK1 activity to drive hepatocellular carcinoma progression

Abstract Hepatocellular carcinoma (HCC) is one of the common malignancy and lacks effective therapeutic targets. Here, we demonstrated that ectopic expression of trophinin-associated protein (TROAP) dramatically drove HCC cell growth assessed by foci formation in monolayer culture, colony formation...

Full description

Bibliographic Details
Main Authors: Lei Li, Jia-Ru Wei, Ye Song, Shuo Fang, Yanyu Du, Zhuo Li, Ting-Ting Zeng, Ying-Hui Zhu, Yan Li, Xin-Yuan Guan
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03422-3